Frequently Asked Questions about Tirzepatide
1. How is Tirzepatide administered?
Tirzepatide is a once-weekly subcutaneous injection. Most patients find the process simple and relatively painless, as it uses a very small needle. It can be self-administered in the abdomen, thigh, or upper arm.
2. How much weight can I expect to lose?
While results vary based on your starting weight and lifestyle, clinical trials showed that many participants lost between 15% and 22.5% of their body weight over 72 weeks. Most patients begin seeing noticeable changes within the first few weeks of treatment as the dosage is gradually increased.
3. What are the most common side effects?
Because Tirzepatide affects the digestive system, the most common side effects are:
Nausea
Diarrhea or constipation
Decreased appetite
Indigestion or "sulfur burps"
Most side effects are mild to moderate and typically occur when you first start the medication or when your dose is increased. They usually subside as your body adjusts.
4. How does Tirzepatide differ from Semaglutide (Ozempic/Wegovy)?
Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual-agonist, meaning it targets both GLP-1 and GIP receptors. By activating two hormone pathways instead of one, Tirzepatide often provides more potent appetite suppression and better blood sugar regulation for many individuals.
5. Do I need to follow a specific diet?
You don't need a "restrictive" diet, but Tirzepatide works best when paired with a healthy, protein-rich eating plan and regular physical activity. Because you will feel full faster, focusing on high-quality nutrients ensures your body stays energized as the pounds come off.
6. Who should NOT take Tirzepatide?
You should avoid Tirzepatide if you or any of your family members have ever had Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It is also not recommended for those who are pregnant, breastfeeding, or have a history of pancreatitis.
7. What happens if I stop taking it?
Weight loss medications are designed for long-term metabolic health. If you stop taking the medication without a long-term maintenance plan, hunger hormones may return to their previous levels. At Mage, we work with you to develop a "tapering" or maintenance strategy to help you keep the weight off for good.
8. Do I need to see a doctor in person?
No. Through Mage, you can complete your medical intake and consult with a licensed healthcare provider entirely online. If you are a candidate, your prescription is sent directly to a pharmacy and shipped to your door.